The Romans establish a military fort and settlement called Ceuclum at the confluence of the Meuse and Niers rivers.
A substantial stone bridge is constructed at Cuijk, one of the few known Roman bridges over the Meuse.
As Roman control over the region weakens, Frankish groups gradually settle in and around Cuijk.
Cuijk appears in early medieval documents as a settlement of growing regional importance.
The noble Van Cuijk family establishes itself as a powerful regional dynasty, building a castle and asserting territorial authority.
Cuijk receives formal town privileges, marking its recognition as an urban center with associated legal and economic rights.
Following disputes and shifting feudal allegiances, Cuijk and its surrounding lands come under the control of the Duchy of Brabant.
The construction of the St. Martinuskerk (St. Martin's Church) in Cuijk is completed, giving the town a substantial Gothic church at its center.
Cuijk experiences military occupation, sieges, and destruction as Spanish and Dutch forces contest control of the Meuse region.
Between 1911 and 1913, St. Martin's Church in Cuijk was extended with two new front towers, giving the medieval church its distinctive twin-towered silhouette. The older original tower at the rear of the building was preserved and later repurposed as a church museum.
The extension of the Dutch railway network reaches Cuijk, connecting the town to Nijmegen and beyond.
Allied forces liberate Cuijk from German occupation during the advance through the Netherlands.
The heavily damaged tower of Cuijk's medieval Sint Martinus church, a landmark battered during the fighting, was repaired in the years after liberation.
Cuijk experiences steady population growth and the expansion of local industry during the postwar economic recovery.
Cuijk undergoes municipal boundary changes and infrastructural modernization, including new roads and public facilities.
Cuijk becomes part of a larger merged municipality combining several surrounding villages under one local government.
Cuijk loses its status as an independent municipality and becomes part of the newly formed municipality of Land van Cuijk.
St. Martin's Church, dedicated to Saint Martin of Tours, grew over generations from an earlier chapel into a sizeable Gothic structure with a tall tower that dominated the skyline of Cuijk. Built largely of brick and local stone, it served as the spiritual and civic heart of the town, standing near the marketplace and the old town walls. Its completion reflects the growing prosperity and status of Cuijk following the granting of town rights, and the church would go on to witness centuries of religious change, including the turmoil of the Reformation and the Eighty Years' War. Much of the structure would later suffer damage in conflicts, notably during the Second World War, but the church's medieval core remained a lasting symbol of the town's identity.